Monogenic disorders are diseases or syndromes where the disease pathology is caused by a single mutated gene. While not all young strokes are caused by monogenic disorders, some of them have this in common. Understanding the genetic foundation of young strokes can be essential in prevention and treatment in these diseases.
Some of the monogenic disorders under investigation through the YGSA are:
Multi-Systemic Smooth Muscle Disorder (MSMDS)
COL4A1
https://www.gouldsyndrome.org/
Generalized Arterial Calcification of Infancy (GACI)